abstract：:Hyperlipidemic patients often have an accelerated esterified cholesterol transfer (ECT) from high density lipoproteins (HDL) to very low (VLDL) and low density lipoproteins (LDL). We investigated the effect of simvastatin on ECT in twelve normolipidemic subjects. After 6 weeks of simvastatin administration, ECT was de...

journal_title：Atherosclerosis

authors： Ahnadi CE,Berthezène F,Ponsin G

更新日期：1993-03-01 00:00:00

abstract：:It has been shown that triglyceride levels are one of the determinants of factor VII levels. In this study we have simultaneously evaluated, in a group of 102 healthy individuals, the different forms of factor VII, namely factor VII mass, factor VII coagulant activity, activated factor VII double-chain form and factor...

journal_title：Atherosclerosis

authors： Negri M,Arigliano PL,Talamini G,Carlini S,Manzato F,Bonadonna G

更新日期：1993-02-01 00:00:00

abstract：:Familial defective apolipoprotein B-100 (FDB) is a dominantly inherited disorder associated with hypercholesterolemia, in which substitution of the amino acid glutamine for arginine at position 3500 in the apoprotein B molecule results in LDL particles which bind poorly to the LDL receptor. To date, patients with FDB ...

journal_title：Atherosclerosis

authors： Schmidt EB,Illingworth DR,Bacon S,Mahley RW,Weisgraber KH

更新日期：1993-01-25 00:00:00

abstract：:A chondroitin sulfate-dermatan sulfate proteoglycan was isolated from bovine aorta intima by extraction of the tissue with 4 M guanidine hydrochloride. The proteoglycan was purified by CsCl isopycnic centrifugation followed by gel filtration and ion exchange chromatography. A monoclonal antibody C8F4 was developed to ...

journal_title：Atherosclerosis

authors： Radhakrishnamurthy B,Jeansonne N,Tracy RE,Berenson GS

更新日期：1993-01-25 00:00:00

abstract：:Simvastatin, an inhibitor of HMG CoA reductase, lowers the plasma total cholesterol and LDL-cholesterol concentration in familial hypercholesterolemic patients. The efficacy of the drug shows considerable inter-individual variation, however. In this study we have assessed the influence of certain LDL-receptor gene mut...

journal_title：Atherosclerosis

authors： Jeenah M,September W,Graadt van Roggen F,de Villiers W,Seftel H,Marais D

更新日期：1993-01-04 00:00:00

abstract：:The effect of administration of probucol in preventing intimal thickening of rabbit carotid artery after balloon catheter injury and the mechanism of action of the drug were studied. Groups of 6 male New Zealand-White rabbits were given normal diet (Group I), high cholesterol diet (Group II) or high cholesterol diet p...

journal_title：Atherosclerosis

authors： Shinomiya M,Shirai K,Saito Y,Yoshida S

更新日期：1992-12-01 00:00:00

abstract：:The effect of 4 months of low-dose probucol treatment (250 mg/day) on LDL oxidation and on plasma-HDL cholesterol was studied in a prospective, double-blind, randomized, placebo-controlled trial involving 26 male volunteers. LDL samples isolated at baseline and at 4 months were subjected to in vitro tests of LDL oxida...

journal_title：Atherosclerosis

authors： Cristol LS,Jialal I,Grundy SM

更新日期：1992-11-01 00:00:00

abstract：:Blood cells express a cell membrane protein, termed homologous restriction factor 20 (HRF20) and identical to CD59, that can inhibit complement C5b-9 insertion into their membranes. In this report, we investigated by immunohistochemistry whether CD59 was present on cells in human atherosclerotic lesions since membrano...

journal_title：Atherosclerosis

authors： Seifert PS,Roth I,Schmiedt W,Oelert H,Okada N,Okada H,Bhakdi S

更新日期：1992-10-01 00:00:00

abstract：:A study conducted in 1953 by one of the authors (H.S.M. Uhl) reported that orally administered ethylenediamine tetraacetic acid (EDTA) both prevented the accumulation of cholesterol in the liver of cholesterol-fed rabbits and caused the removal of accumulated cholesterol from the liver. These observations were made in...

journal_title：Atherosclerosis

authors： Uhl HS,Dysko RC,St Clair RW

更新日期：1992-10-01 00:00:00

abstract：:Whether an association, causative or not, exists between the level of serum selenium and the risk of ischaemic heart disease (IHD) remains unsettled. We investigated the issue in a cohort of 3387 males aged 53-74 years (mean 63). Based on information about health status, life-style and socioeconomic factors given in a...

journal_title：Atherosclerosis

authors： Suadicani P,Hein HO,Gyntelberg F

更新日期：1992-09-01 00:00:00

abstract：:Evidence for chemical and biological heterogeneity of human plasma lipoprotein density classes has been steadily accumulating over the last 15 years. Furthermore, several recent reports have indicated potential clinical significance of certain lipoprotein subspecies as either atherogenic or antiatherogenic. It is gene...

journal_title：Atherosclerosis

authors： Koren E,Armstrong VW,Mueller G,Wilson PR,Schuff-Werner P,Thiery J,Eisenhauer T,Alaupovic P,Seidel D

更新日期：1992-08-01 00:00:00

abstract：:We studied the effect of gemfibrozil on the compositions of VLDL, LDL and distribution of LDL subspecies in type II hyperlipidemic patients. Gemfibrozil significantly lowered serum triglyceride levels in this group of patients who had normal to moderately elevated triglyceride prior to therapy. Gemfibrozil also change...

journal_title：Atherosclerosis

authors： Tsai MY,Yuan J,Hunninghake DB

更新日期：1992-07-01 00:00:00

abstract：:The fatty acid composition of adipose tissue from 4114 men and women across 22 districts of Scotland is described. A biopsy of subcutaneous adipose tissue was obtained from the upper arm using a skin biopsy punch. Overall the proportion of saturated fatty acids was lower in women and those of monounsaturated and polyu...

journal_title：Atherosclerosis

authors： Tavendale R,Lee AJ,Smith WC,Tunstall-Pedoe H

更新日期：1992-06-01 00:00:00

abstract：:The insulin response to a standard oral glucose tolerance test (OGTT) and other anthropometric and biochemical risk factors for coronary heart disease (CHD) were measured in a random sample of 107 Edinburgh men, who were initially studied in 1976 when they were 40 and who were reexamined in 1988-89. Fasting glucose an...

journal_title：Atherosclerosis

authors： Hargreaves AD,Logan RL,Elton RA,Buchanan KD,Oliver MF,Riemersma RA

更新日期：1992-05-01 00:00:00

abstract：:The change of acid cholesteryl ester hydrolase activity in mononuclear leukocyte following treatment of diabetes mellitus was studied in 21 patients with non-insulin-dependent diabetes mellitus (NIDDM). Enzyme activity before treatment in the patients was significantly lower than that in 14 age-matched healthy subject...

journal_title：Atherosclerosis

authors： Onuma T,Tsutsui M,Boku A,Yanada A,Ochiai S,Takebe K

更新日期：1992-02-01 00:00:00

abstract：:The effects of insulin and insulin-like growth factor I (IGF-I) on migration, proliferation and tube-forming activity of endothelial cells were investigated, by using bovine carotid artery endothelial cells. Migration was assayed by a filter membrane technique and tube formation was assayed by a quantitative angiogene...

journal_title：Atherosclerosis

authors： Nakao-Hayashi J,Ito H,Kanayasu T,Morita I,Murota S

更新日期：1992-02-01 00:00:00

abstract：:Low density lipoprotein (LDL) and high density lipoprotein (HDL3) were tested for their ability to induce inositol phospholipid turnover and inositol phosphate production in bovine aortic endothelial cells (BAEC). The production of inositol phosphates following hydrolysis of the phosphoinositides was demonstrated by t...

journal_title：Atherosclerosis

authors： Myers DE,Fidge NH,Stanton H,Larkins RG

更新日期：1992-01-01 00:00:00

abstract：:The efficacy and safety of bezafibrate were evaluated in 83 patients with type IIa, IIb, or IV hyperlipoproteinemia. Following a 12- to 14-week placebo period on a coronary-prudent diet (Period 1), patients were assigned randomly to receive either bezafibrate 600 mg/day or placebo, plus diet in a double-blind, 12-week...

journal_title：Atherosclerosis

authors： Bradford RH,Goldberg AC,Schonfeld G,Knopp RH

更新日期：1992-01-01 00:00:00

abstract：:Heritability of plasma apolipoprotein (apo) A-I, apo B, and low density lipoprotein (LDL) subclasses and concordance for lipoprotein(a) excess were assessed in 109 monozygotic (MZ) and 113 dizygotic (DZ) twin pairs participating in the third examination of the National Heart, Lung, and Blood Institute Twin Study. The ...

journal_title：Atherosclerosis

authors： Lamon-Fava S,Jimenez D,Christian JC,Fabsitz RR,Reed T,Carmelli D,Castelli WP,Ordovas JM,Wilson PW,Schaefer EJ

更新日期：1991-11-01 00:00:00

abstract：:Lipid and apoprotein composition of four very low density lipoprotein (VLDL) subfractions decreasing in Sf value were evaluated in the fasting state in 12 normolipidemic Pima Indians (6 M, 6 F, age 39 +/- 1.7 yrs) (mean +/- SEM) with non-insulin-dependent diabetes mellitus (NIDDM) in poor glycemic control (HbA1 9.8 +/...

journal_title：Atherosclerosis

authors： Patti L,Swinburn B,Riccardi G,Rivellese AA,Howard BV

更新日期：1991-11-01 00:00:00

abstract：:Oxidation of low density lipoprotein (LDL) leads to more rapid uptake by arterial wall macrophages and foam cell formation. Inhibiting LDL oxidation may impede these processes and offers a new mechanism to retard atherogenesis. The 21-aminosteroids, derived from methylprednisolone, are potent inhibitors of free radica...

journal_title：Atherosclerosis

authors： Fisher M,Levine PH,Doyle EM,Arpano MM,Hoogasian JJ

更新日期：1991-10-01 00:00:00

abstract：:Regulation of expression of the genes for the low density lipoprotein receptor (LDLR) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR) is of central importance in the control of cholesterol metabolism and thus in influencing the concentration of low density lipoprotein in the plasma. This can be studied by i...

journal_title：Atherosclerosis

authors： Le Cras TD,Gherardi E,Bowyer DE

更新日期：1991-09-01 00:00:00

abstract：:We present the case of a 42-year-old male with familial hypercholesterolemia (FH) who had received long-term low-density lipoprotein (LDL)-apheresis before death occurred, presumably from an arrhythmia. He had been treated with double filtration plasmapheresis (DFPP) for 4 years and selective LDL adsorbent plasmaphere...

journal_title：Atherosclerosis

authors： Koga N,Iwata Y

更新日期：1991-09-01 00:00:00

abstract：:We describe a rapid screening procedure to identify known DNA sequence changes in individuals diagnosed as having heterozygous familial hypercholesterolaemia (FH). The screening is made possible by combining a rapid DNA extraction protocol and small scale polymerase chain reaction DNA amplification, followed by oligon...

journal_title：Atherosclerosis

authors： Talmud P,Tybjaerg-Hansen A,Bhatnagar D,Mbewu A,Miller JP,Durrington P,Humphries S

更新日期：1991-08-01 00:00:00

abstract：:Serum and aortic tissue cholesterol levels in parallel with aortic relaxation to endothelium-dependent and independent drugs were determined in Watanabe heritable hyperlipidemic (WHHL) rabbits in comparison with New Zealand (N.Z.) normocholesterolemic rabbits, aged 4-14 months. Serum cholesterol was elevated (626 +/- ...

journal_title：Atherosclerosis

authors： Chinellato A,Banchieri N,Pandolfo L,Ragazzi E,Froldi G,Norido F,Caparrotta L,Fassina G

更新日期：1991-08-01 00:00:00

abstract：:Small high density lipoproteins (HDL) with pre-beta electrophoretic mobility (pre-beta HDL) have recently been shown to be the primary acceptor of cholesterol from cultured cells. We studied the metabolism of these particles by incubating serum at 37 degrees C in the presence and absence of active lecithin: cholestero...

journal_title：Atherosclerosis

authors： Neary R,Bhatnagar D,Durrington P,Ishola M,Arrol S,Mackness M

更新日期：1991-07-01 00:00:00

abstract：:The hypolipidemic response of rice bran oil (RBO) was investigated in nonhuman primates fed semi-purified diets containing blends of oils which included RBO at 0-35% Kcals as dietary fat. The studies demonstrated the following: (a) the degree of reduction of serum total cholesterol (TC) and low density lipoprotein cho...

journal_title：Atherosclerosis

authors： Nicolosi RJ,Ausman LM,Hegsted DM

更新日期：1991-06-01 00:00:00

abstract：:We studied the kinetic parameters of high density lipoprotein (HDL) cholesteryl esters in the cebus monkey, an animal species with high plasma cholesteryl ester transfer activity. HDL were radiolabeled with cholesteryl [1-14C]oleate and intravenously administered to 4 cebus monkeys. The calculated fractional catabolic...

journal_title：Atherosclerosis

authors： Terpstra AH,Stucchi AF,Nicolosi RJ

更新日期：1991-06-01 00:00:00

abstract：:In order to study the connection between homocysteine and lipid metabolism in atherosclerosis, homocysteine was determined in lipoprotein fractions from men with hypercholesterolemia. All lipoprotein fractions contain a considerably higher level of homocysteine in hypercholesterolemia, compared to normolipemic men, va...

journal_title：Atherosclerosis

authors： Olszewski AJ,McCully KS

更新日期：1991-05-01 00:00:00

abstract：:The association between serum selenium concentration and a number of coronary heart disease risk factors is studied in 364 males from southern Italy participating in the Olivetti Heart Study. Selenium correlates positively and significantly with serum cholesterol (r = 0.120; P = 0.022), and this positive association p...

journal_title：Atherosclerosis

authors： Jossa F,Trevisan M,Krogh V,Farinaro E,Giumetti D,Fusco G,Galasso R,Panico S,Frascatore S,Mellone C

更新日期：1991-04-01 00:00:00

abstract：:We have recently established that low density lipoprotein (LDL) of most patients with coronary atherosclerosis differs from the LDL of most healthy subjects by its ability to cause primary atherosclerotic changes, i.e. the accumulation of intracellular cholesterol in the cells of smooth muscle origin cultured from una...

journal_title：Atherosclerosis

authors： Orekhov AN,Tertov VV,Mukhin DN

更新日期：1991-02-01 00:00:00

abstract：:LDL and HDL became more fluid when health, free-living, premenopausal women were fed reduced fat diets with higher proportions of polyunsaturated fatty acids. Lipoproteins were isolated from plasma of 31 female subjects fed one of two sets of diets from typical U.S.A. foods with P/S ratios of 0.3 or 1.0. All subjects ...

journal_title：Atherosclerosis

authors： Berlin E,Judd JT,Nair PP,Jones DY,Taylor PR

更新日期：1991-02-01 00:00:00

abstract：:To asses the relationship between fibrinogen, factor VII coagulant (VIIc) activity and extent of coronary artery disease, we studied 43 white males shown to have greater than 50% stenosis of at least one major coronary artery. Thirty six had a definite history of myocardial infarction at least 3 months earlier and wer...

journal_title：Atherosclerosis

authors： Broadhurst P,Kelleher C,Hughes L,Imeson JD,Raftery EB

更新日期：1990-12-01 00:00:00

abstract：:Whole blood and plasma viscosity, red cell aggregability and deformability, and plasma fibrinogen have been compared between 20 patients with heterozygous familial hypercholesterolaemia (FH), without clinical arterial disease, and 20 age- and sex-matched controls. Plasma fibrinogen was elevated in FH, associated with ...

journal_title：Atherosclerosis

authors： Jay RH,Rampling MW,Betteridge DJ

更新日期：1990-12-01 00:00:00

abstract：:The effects of lovastatin therapy on concentrations and compositions of lipoproteins were examined in 14 patients with heterozygous familial hypercholesterolemia. The drug lowered plasma levels of cholesterol in total plasma, very low density + intermediate density lipoproteins (VLDL + IDL) and low density lipoprotein...

journal_title：Atherosclerosis

authors： Nozaki S,Vega GL,Haddox RJ,Dolan ET,Grundy SM

更新日期：1990-10-01 00:00:00

abstract：:Large (Sf greater than 100) and small (Sf 100-20) very low density lipoprotein (VLDL) particles were isolated by density gradient ultracentrifugation and characterized chemically in 8 patients with primary hypertriglyceridemia before and after 6 weeks treatment with 4 grammes daily of nicotinic acid (NA). Concomitant ...

journal_title：Atherosclerosis

authors： Tornvall P,Hamsten A,Johansson J,Carlson LA

更新日期：1990-10-01 00:00:00

abstract：:The effect of low dose (600 mg/day) alpha-tocopheryl nicotinate on serum lipoprotein(a) (Lp(a] concentration was studied in 28 hyperlipidaemic patients. Serum lipids, lipoproteins and apolipoproteins, except for Lp(a), tended to increase after treatment. In particular, the changes in HDL-cholesterol and apo C-II level...

journal_title：Atherosclerosis

authors： Noma A,Maeda S,Okuno M,Abe A,Muto Y

更新日期：1990-10-01 00:00:00

abstract：:It has been reported that total cholesterol (Chol) response to probucol is greater in familial hypercholesterolemic (FH) patients with apo E4 than in those without apo E4. We further examined the effect of probucol on plasma triglyceride (TG) and lipoprotein-Chol levels as well as total Chol levels in heterozygous FH ...

journal_title：Atherosclerosis

authors： Eto M,Sato T,Watanabe K,Iwashima Y,Makino I

更新日期：1990-09-01 00:00:00

abstract：:The internal mammary artery (IMA) is less prone to intimal thickening than coronary arteries and is routinely used in coronary bypass surgery. To resolve whether morphologic differences can explain why IMA develops less intimal thickening, morphometric measurement of the left anterior descending coronary artery (LAD) ...

journal_title：Atherosclerosis

authors： Svendsen E,Dregelid E,Eide GE

更新日期：1990-08-01 00:00:00

abstract：:We investigated the possibility that established atherosclerosis and xanthomas in mature WHHL rabbits could be suppressed or even regressed when their serum cholesterol levels were kept extremely low. Ten-month-old WHHL rabbits were divided into 3 groups, i.e. control rabbits, sacrificed at age 10 months, and placebo ...

journal_title：Atherosclerosis

authors： Shiomi M,Ito T,Watanabe Y,Tsujita Y,Kuroda M,Arai M,Fukami M,Fukushige J,Tamura A

更新日期：1990-07-01 00:00:00